Sporanox

Sporanox is a triazole derivative with a broad spectrum of antifungal activity that inhibits the growth of a broad range of fungi that are pathogenic in humans

Indications

Treatment of pityriasis versicolor and dermatophytoses caused by organisms susceptible to itraconazole (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), e.g. tinea pedis, tinea cruris, tinea corporis, tinea manuum, and onychomycosis caused by dermatophytes and/or yeasts. Sporanox is also indicated Treatment of candidosis (vaginal and oral), histoplasmosis and systemic fungal conditions

Price

100mg capsules, £CS
10mg/ml (150ml) oral liquid, price on application

Systemic antifungals

All Systemic antifungals

Pfizer

Diflucan

Diflucan contains fluconazole, a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole. Fluconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems