Dermatology Handbook

The professional's guide to product selection

Immunosuppressants

Methotrexate

Methotrexate

Methotrexate is an antimetabolite, which acts principally by competitively inhibiting the enzyme, dihydrofolate reductase. In the process of DNA synthesis and cellular replication, folic acid must be reduced to tetrahydrofolic acid by this enzyme, and inhibition by methotrexate interferes with tissue cell reproduction. Actively proliferating tissues such as malignant cells are generally more sensitive to this effect of methotrexate. It also inhibits antibody synthesis. Methotrexate also has immunosuppressive activity, in part possibly as a result of inhibition of lymphocyte multiplication

Neoral

Neoral

Neoral contains ciclosporin (also known as ciclosporin A), which is a cyclic polypeptide consisting of 11 amino acids. It is an immunosuppressive agent licensed for the prevention of graft rejection following heart, kidney, pancreas, bone marrow and lung in transplants. Benificial effects of ciclosporin therapy have also been shown in patients with severe psoriasis, atopic dermatitis, rheumatoid arthritis and nephrotic syndrome, conditions that may be considered to have an immunological mechanism