The professional's guide to product selection
Pimecrolimus is a lipophilic anti-inflammatory ascomycin macrolactam derivative and a cell selective inhibitor of the production and release of pro-inflammatory cytokines. Its skin-selective pharmacological profile is different to that of corticosteroids
The formula of Eucerin AtoControl Acute Care Cream is a skin-calming complex based on four key ingredients: Omega-6 Fatty Acids, Decandiol, Licochalcone A and Menthoxypropanediol. Irritated and reddened skin is calmed and soothed, helping to improve mild to moderate flare-ups significantly.
The mechanism of action of tacrolimus in atopic dermatitis is not fully understood. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. Via its binding to a specific cytoplasmic immunophilin (FKBP12), tacrolimus inhibits calcium-dependent signal transduction pathways in T cells, thereby preventing the transcription and synthesis of IL-2, IL-3, IL-4, IL-5 and other cytokines such as GM-CSF, TNFα and IFNγ. In patients with atopic dermatitis, improvement of skin lesions during treatment with tacrolimus ointment was associated with reduced Fc receptor expression on Langerhans cells and a reduction of their hyperstimulatory activity towards T cells. Tacrolimus ointment does not affect collagen synthesis in humans
