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Kyntheum

... IL-25, resulting in inhibition of the inflammation and clinical symptoms associated with psoriasis. IL-17RA is a protein expressed on the cell surface and is a required component of receptor complexes used by multiple IL-17 family cytokines. IL-17 family cytokine concentrations have been reported to be increased in psoriasis. Blocking IL-17RA inhibits IL-17 cytokine-induced responses resulting ... More Info

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Calcipotriol 50 micrograms/ml Ointment

Calcipotriol is a vitamin D derivative. In vitro data show that calcipotriol induces differentiation and suppresses proliferation of keratinocytes. The effect of calcipotriol in psoriasis is ascribed mainly to this. 

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Dovobet Gel

Dovobet Gel contains a combination of calcipotriol and betamethasone dipropionate. Calcipotriol is a vitamin D analogue. In vitro data suggest that calcipotriol induces differentiation and suppresses proliferation of keratinocytes. This is the proposed basis for its effect in psoriasis. Betamethasone dipropionate is a potent topical corticosteroid with anti-inflammatory, antipruritic ... More Info

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Dithrocream

Dithrocream contains dithranol, a treatment used in psoriasis for over 70 years. While its precise mode of action is still to be confirmed, it has been shown to inhibit DNA replication, cellular respiration and key cellular enzymes, e.g. glucose-6-phosphate dehydrogenase

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AproDerm Emollient Cream

AproDerm Emollient Cream is a soap substitute and an occlusive, leave-on emollient that is free from SLS, parabens, chlorocresol, fragrances and colours. Suitable from birth AproDerm Emollient Cream soothes, moisturises and protects the skin of those suffering from eczema, psoriasis and other dry skin conditions. Contains white soft paraffin 15% and liquid paraffin 6%.

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Tremfya

... IL-23 are elevated in the skin of patients with plaque psoriasis. In in vitro models, guselkumab was shown to inhibit the bioactivity of IL-23 by blocking its interaction with cell surface IL-23 receptor, disrupting IL-23-mediated signaling, activation and cytokine cascades. Guselkumab exerts clinical effects in plaque psoriasis through blockade of the IL-23 cytokine pathway.