Dermatology Handbook

The professional's guide to product selection

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The mechanism of action of tacrolimus in atopic dermatitis is not fully understood. While
the following have been observed, the clinical significance of these observations in atopic
dermatitis is not known. Via its binding to a specific cytoplasmic immunophilin (FKBP12),
tacrolimus inhibits calcium-dependent signal transduction pathways in T cells, thereby
preventing the transcription and synthesis of IL-2, IL-3, IL-4, IL-5 and other cytokines such as
GM-CSF, TNF-α and IFN-γ. In patients with atopic dermatitis, improvement of skin lesions
during treatment with tacrolimus ointment was associated with reduced Fc receptor
expression on Langerhans cells and a reduction of their hyperstimulatory activity towards T
cells. Tacrolimus ointment does not affect collagen synthesis in humans.


For the treatment of dermatoses, including intertrigo, eczema, seborrhoeic dermatitis, atopic dermatitis, and pruritis ani et vulvae, in which infection with Candida albicans is a factor. For the treatment of severe nappy rash in which infection with C. albicans is a factor

Canesten Hydrocortisone

Canesten Hydrocortisone is a combination of clotrimazole and hydrocortisone acetate. Clotrimazole belongs to a group of medicines called imidazoles, which destroy the fungi and some bacteria that cause skin infections. Hydrocortisone acetate is a mild steroid which reduces swelling, redness and itching associated with inflammation of the skin


Daktacort is a compound of hydrocortisone and miconazole nitrate. Miconazole is a potent broad-spectrum antifungal and antibacterial agent with marked activity against dermatophytes, pathogenic yeasts (e.g. Candida spp.) and many Gram-positive bacteria, including most strains of Streptococcus and Staphylococcus. Hydocortisone is a widely used topical anti-inflammatory of value in the treatment of inflammatory skin conditions including atrophic and infantile eczema, contact sensitivity reactions and intertrigo

Epiduo Gel

Epiduo contains a combination of adapalene and benzoyl peroxide. Adapalene is a retinoid-like compound that is a potent modulator of cellular differentiation and keratinisation and has anti-inflammatory properties. This profile suggests that the cell-mediated inflammatory component of acne is reduced by adapalene. Benzoyl peroxide has been shown to have antimicrobial activity, particularly against Propionibacterium acnes, which is abnormally present in the acne-affected pilosebaceous unit. In addition, benzoyl peroxide has demonstrated exfoliative and keratolytic activities and is sebostatic, counteracting the excessive sebum production associated with acne