Dermatology Handbook

The professional's guide to product selection

Acitretin (Neotigason)

Teva

Description

Acitretin is a retinoid. Retinol (Vitamin A) is known to be essential for normal epithelial growth and differentiation, though the mode of this effect is not yet established. Both retinol and retinoic acid are capable of reversing hyperkeratotic and metaplastic skin changes. However, these effects are generally only obtained at dosages associated with considerable local or systemic toxicity. Acitretin, a synthetic aromatic derivative of retinoic acid, has a favourable therapeutic ratio, with a greater and more specific inhibitory effect on psoriasis and disorders of epithelial keratinisation. The usual therapeutic response to acitretin consists of desquamation (with or without erythema) followed by more normal re-epithelialisation. Acitretin is the main active metabolite of etretinate.

Indications

For the treatment of severe extensive psoriasis, which is resistant to other forms of therapy, palmo-plantar pustular psoriasis, severe congenital ichthyosis and severe Darier’s disease (keratosis follicularis)

Price

10mg (60), £30.42; 25mg (60), £58.78

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