Acea

Contains 0.75% metronidazole, which is an established antibacterial agent. It is effective against a variety of organisms including anaerobic bacteria.

Metrogel contains 0.75% metronidazole, which is a topical antibacterial

Brimonidine is a highly selective alpha2-adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenergic receptor than the alpha1-adrenergic receptor. Cutaneous facial application of a highly selective alpha2-adrenergic receptor agonist reduces erythema through direct cutaneous vasoconstriction.

Rozex contains 0.75% metroniazole, an antiprotozoal and antibacterial agent that is active against a wide range of pathogenic microorganisms. The mechanisms of action of metronidazole in rosacea are unknown, but evidence suggests that the effects may be antibacterial and/or anti-inflammatory

Ivermectin is a member of the avermectin class. Avermectin has anti-inflammatory effects by inhibiting lipopolysaccharide-induced production of inflammatory cytokines. Anti-inflammatory properties of cutaneous ivermectin have been observed in animal models of skin inflammation. Ivermectin also causes death of parasites, primarily through binding selectively and with high affinity to glutamate-gated chloride channels, which occur in invertebrate nerve and muscle cells. The mechanism of action of Soolantra in treating the inflammatory lesions of rosacea is not known but may be linked to anti-inflammatory effects of ivermectin as well as causing the death of Demodex mites that have been reported to be a factor in inflammation of the skin