Topical antifungals GSK

Lamisil AT Spray

Lamisil contains terbinafine, an allylamine which has a broad spectrum of antifungal activity. At low concentrations terbinafine is fungicidal against dermatophytes, moulds and certain dimorphic fungi. Its activity against yeasts is fungicidal or fungistatic, depending on the species. Terbinafine interferes specifically with fungal sterol biosynthesis at an early step. This leads to a deficiency in ergosterol and an intracellular accumulation of squalene, resulting in fungal cell death